Ceftiofur Hydrochloride(103980-44-5)
Tlhaloso ea Sehlahisoa
Ceftiofur ke sethibela-mafu sa mofuta oa cephalosporin (moloko oa boraro), se nang le tumello ea ho sebelisoa meriana ea bongaka ba liphoofolo.E ile ea hlalosoa ka lekhetlo la pele ka 1987.
E hanyetsana le enzyme ea beta-lactamase ea lithibela-mafu, 'me e na le ts'ebetso khahlano le libaktheria tsa Gram-positive le Gram-negative.Ho tlalehiloe mefuta ea E. coli e hanyetsanang le ceftiofur.
Ceftiofur Hydrochloride ke mofuta oa letsoai oa hydrochloride oa ceftiofur, semisynthetic, beta-lactamase-stable, wide-spectrum, moloko oa boraro oa cephalosporin e nang le ts'ebetso ea antibacterial.Ceftiofur e tlama le ho tima liprotheine tse tlamang penicillin (PBPs) tse ka har'a lera le ka hare la lerako la sele ea baktheria.Li-PBP ke li-enzyme tse amehang mehatong ea ho qetela ea ho kopanya lerako la sele ea baktheria le ho fetola lerako la sele nakong ea kholo le karohano.Ho se sebetse ha li-PBP ho kena-kenana le khokahano ea liketane tsa peptidoglycan tse hlokahalang bakeng sa matla a lerako la lisele tsa baktheria le ho tiea.Sena se fella ka ho fokola ha lerako la lisele tsa baktheria 'me se baka sele lysis.
| LINTLHA | LIEKETSENG TS'OANELO | LIPHETHO | |
| Ponahalo | Phofo ea Crystalline e tšoeu ho isa ho e tšoeu | Ikamahanya | |
| Boitsebiso | Nako ea ho boloka tlhōrō ea sehlooho ka ho chromatogram e fumanoeng ka tharollo ea teko Correspoonds ho ea tlhōrō e ka sehloohong ho chromatogram e fumanoeng ka tharollo ea litšupiso. | Ikamahanya | |
| Karabelo ea Chloride | Ikamahanya | ||
| Ponahalo ea tharollo | Ho hlaka | Ha e matla ho feta No.1 Turbidity Standard | <1 |
| Mmala | Ha e lefifi ho feta tharollo e tloaelehileng ea Y9 | <8 | |
| Solubility | E qhibiliha ka N, N- Dimethylacetamide, hanyenyane e qhibilihang ka 5% ea sodium bicarbonate le methanol. | Ikamahanya | |
| PH | 2.0~3.0 | 2.2 | |
| Litaba tsa Metsi | 1.5%~4.0% | 1.6% | |
| Specific Optical Rotation | -115°~-127° | -117° | |
| Tšepe e boima | NMT 0.0020% | Ikamahanya | |
| Masalla a ho betsa | NMT 0.20% | 0.15% | |
| Lintho tse amanang | Ho se hloeke ho hoholo | NMT 0.20% | 0.09 |
| Litšila kaofela | NMT 1.50% | 0.38 | |
| Masalla a solvents | Ethyl Acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Tlhahlobo | Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| Chloride | 6.0%~6.5% | 6.2% | |
| Endotoxin ea baktheria | Ka tlase ho 0.20EU/mg | Ikamahanya | |
| Ho beleha | E lumellana le teko | Ikamahanya | |
| Boholo ba likaroloana | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| TS'ELISO | LIPOLELO TSA TEKO LI FIHLELA HO TLHAKISO | ||
