Tranexamic Acid(1197-18-8)
Tlhaloso ea Sehlahisoa
● Tranexamic Acid(1197-18-8)
● Nomoro ea CAS: · 1197-18-8
● EINECS No.: 356.2222
● MF: C8H15NO2
● Sephutheloana: 25Kg / Drum
● Tranexamic acid (TXA) ke moriana o sebelisetsoang ho alafa kapa ho thibela ho lahleheloa ke mali ho feteletseng ho bakoang ke ho sithabela ho hoholo, ho tsoa mali ka mor’a ho pepa, ho buuoa, ho ntša leino, ho tsoa mali a nko le ho ilela khoeli haholo.[2][3]E boetse e sebelisoa bakeng sa angioedema ea lefutso.[2][4]E nkoa ka molomo kapa ka ente ka har'a mothapo.
Mokhoa oa ts'ebetso
Tranexamic acid ke analogue ea maiketsetso ea amino acid lysine.E sebetsa joalo ka antifibrinolytic ka ho tlama libaka tse 'ne ho isa ho tse hlano tsa lysine receptor ho plasminogen.Sena se fokotsa phetoho ea plasminogen ho plasmin, ho thibela ho senyeha ha fibrin le ho boloka moralo oa sebopeho sa matrix sa fibrin. Tranexamic acid e na le hoo e ka bang makhetlo a robeli a ts'ebetso ea antifibrinolytic ea analogue ea khale, ε-aminocaproic acid. ts'ebetso ea plasmin e nang le matla a fokolang (IC50 = 87 mM), 'me e ka thibela sebaka se sebetsang sa urokinase plasminogen activator (uPA) e nang le maemo a holimo (Ki = 2 mM), e leng e 'ngoe ea tse phahameng ka ho fetisisa har'a liprotheine tsohle tsa serine.
Tranexamic acid e sebetsa
Tranexamic acid e sebelisoa hangata ho latela ts'oaetso e kholo.[13]Tranexamic acid e sebelisoa ho thibela le ho phekola tahlehelo ea mali maemong a fapaneng, joalo ka mekhoa ea meno, ho tsoa mali a mangata nakong ea ho ilela khoeli, le ho buuoa ho nang le kotsi e kholo ea ho lahleheloa ke mali.
| Lintho tsa Tlhahlobo | Litekanyetso tsa Pharmacopeial | Sephetho sa Tlhahlobo | |
| LIEKETSENG | Ponahalo: Phofo e tšoeu kapa e batlang e le tšoeu, e kristale | Phofo e tšoeu ea kristale | |
| Sollubility: E qhibiliha ka bolokolohi metsing le ka har'a glacial acetic acid, hoo e batlang e sa qhibilihe ka har'a acetone le ethanol (96%). | Feta | ||
| TS'ELISO TS'OANE | Infrared Absorption Spectrophotometry: spectrum ea IR e lumellana le Tranexamic acid CRS | Feta | |
| TEKO | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Lintho tse Amanang (HPLC2.2.29) | Tšilafalo A≤ 0.1 % | Ha e fumanwe | |
| Tšilafalo B≤ 0.2% | 0.03% | ||
| Litšila C Litšila tse sa boleloang≤ 0.10% Litšila D Litšila tse ling | 0.002% 0.001% Ha e fumanwe | ||
| Kakaretso ea litšila tse sa boleloang≤ 0.2% | 0.003% | ||
| Li-Halides li Hlahisoa e le Chlorides | ≤140ppm | <140ppm | |
| Tahlehelo ka ho Omisa | ≤0.5% | 0.026% | |
| Molora oa Sulfate | ≤0.1% | 0.027% | |
| TLHOKOMELO | E lokela ho ba ka hare ho (Omisitsoeng e thehiloeng) 99.0% 〜101.0% | 100.1% | |
