Doxycycline Hyclate(24390-14-5)
Tlhaloso ea Sehlahisoa
● Doxycycline Hcl ke antibacterial spectrum e haufi haholo le Tetracycline le Terramycin, empa e na le phello e molemo, e-ba hlokolosi ho Staphylococcus Aureus ea tetracycline-resistant, oxytetracycline, nako e telele. tshwaetso matšoafo, a hlobaetsang le tonsillitis, mycoplasma pneumonia, tšoaetso pampitšana moroto, chefo mali, bacillary letšollo, a hlobaetsang le lymphadenitis, joalo-joalo E ratoa haholo ke Nephropathy mokuli ka lebaka la chefo lona e sa bonahaleng bakeng sa liphio.
● Doxycycline Hyclate ke mofuta oa letsoai oa hyclate oa doxycycline, e leng lithibela-mafu tsa maiketsetso tsa tetracycline tse ngata tse bontšang tšebetso e thibelang likokoana-hloko.Doxycycline hyclate e tlamella ka ho kgutlela ho 30S ribosomal subunit, mohlomong le 50S ribosomal subunit hape, ka tsela eo e thibela tlamahano ya aminoacyl-tRNA ho mRNA-ribosome complex.Sena se lebisa ho thibelo ea protheine synthesis.Ntle le moo, moemeli enoa o bonts'itse thibelo ea ts'ebetso ea collagenase.
Kopo
Doxycycline Hyclate e sebelisoa ho phekola mafu a mangata a sa tšoaneng a baktheria, ho akarelletsa le a bakang makhopho.Doxycycline Hyclate e boetse e sebelisoa ho thibela malaria.Doxycycline Hyclate e tsejoa e le lithibela-mafu tsa tetracycline.E sebetsa ka ho emisa kholo ea baktheria.Sethibela-mafu sena se tšoara mafu a baktheria feela.
| Lintho | Litlhaloso | Liphetho |
| Ponahalo | Yellow crystalline phofo | E lumellana |
| Boitsebiso | TLC | E lumellana |
| sulfuric acid reaction, 'mala o mosehla oa hlaha | E lumellana | |
| e fana ka karabelo ea chloride | E lumellana | |
| PH | 2.0~3.0 | 2.3 |
| Ho monya ho itseng | ho 349nm e(1%) 300~355 | 320 |
| Potoloho e khethehileng ea optical | -105 ~ -120° | -110 ° |
| Litšepe tse boima: | ≤50ppm | <20ppm |
| Litšila tse monyang khanya | ho 490nm ≤0.07 | 0.03 |
| Lintho tse amanang | 6-epidoxycycline ≤2.0%metacycline ≤2.0% 4-epidoxycycline ≤0.5% (ep5) 4-epi-6-epidoxycycline ≤0.5% (ep5) oxytetracycline ≤0.5% (ep5) litšila tse ling ≤0.5% litšila tse sa tsejoeng ≤0.1% (ep5) | 1.6%0.1% Ha ea fumanoa Ha ea fumanoa Ha ea fumanoa Ha ea fumanoa Ha ea fumanoa |
| Ethanol | 4.3~6.0% (m/m) | 4.5% |
| Molora o nang le sulphated | ≤0.4% | 0.05% |
| Metsi | 1.4~2.8% | 1.8% |
| Tlhahlobo | 95.0 ~ 102.0% ( c22h25cln2o8) e thehiloeng ho anhydrous, ntho e se nang ethanol | 98.6% |
| Qetello | E lumellana le USP32 | |
